Implementation and Comparison of Two Pharmacometric Tools for Model-Based Therapeutic Drug Monitoring and Precision Dosing of Daptomycin

• Main Authors: Justine Heitzmann (Author), Yann Thoma (Author), Romain Bricca (Author), Marie-Claude Gagnieu (Author), Vincent Leclerc (Author), Sandrine Roux (Author), Anne Conrad (Author), Tristan Ferry (Author), Sylvain Goutelle (Author)
• Format: Book
• Published: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Daptomycin is a candidate for therapeutic drug monitoring (TDM). The objectives of this work were to implement and compare two pharmacometric tools for daptomycin TDM and precision dosing. A nonparametric population PK model developed from patients with bone and joint infection was implemented into...