Bio-Distribution and Pharmacokinetics of Topically Administered γ-Cyclodextrin Based Eye Drops in Rabbits

• Egile Nagusiak: Martin Kallab (Egilea), Kornelia Schuetzenberger (Egilea), Nikolaus Hommer (Egilea), Bhavapriya Jasmin Schäfer (Egilea), Doreen Schmidl (Egilea), Helga Bergmeister (Egilea), Markus Zeitlinger (Egilea), Aimin Tan (Egilea), Phatsawee Jansook (Egilea), Thorsteinn Loftsson (Egilea), Einar Stefansson (Egilea), Gerhard Garhöfer (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2021-05-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

The purpose of this study was to evaluate the ocular pharmacokinetics, bio-distribution and local tolerability of γ-cyclodextrin (γCD) based irbesartan 1.5% eye drops and candesartan 0.15% eye drops after single and multiple topical administration in rabbit eyes. In this randomized, controlled study...