Structure-Activity Relationships of Benzothiazole-Based Hsp90 C-Terminal-Domain Inhibitors

• Main Authors: Jaka Dernovšek (Author), Živa Zajec (Author), Martina Durcik (Author), Lucija Peterlin Mašič (Author), Martina Gobec (Author), Nace Zidar (Author), Tihomir Tomašič (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Heat shock protein 90 (Hsp90) is a chaperone responsible for the maturation of many cancer-related proteins, and is therefore an important target for the design of new anticancer agents. Several Hsp90 N-terminal domain inhibitors have been evaluated in clinical trials, but none have been approved as...