Structure-Activity Relationships of Benzothiazole-Based Hsp90 C-Terminal-Domain Inhibitors

• Autori principali: Jaka Dernovšek (Autore), Živa Zajec (Autore), Martina Durcik (Autore), Lucija Peterlin Mašič (Autore), Martina Gobec (Autore), Nace Zidar (Autore), Tihomir Tomašič (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2021-08-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Heat shock protein 90 (Hsp90) is a chaperone responsible for the maturation of many cancer-related proteins, and is therefore an important target for the design of new anticancer agents. Several Hsp90 N-terminal domain inhibitors have been evaluated in clinical trials, but none have been approved as...