Thiazolidin-2-cyanamides derivatives as novel potent Escherichia coli β-glucuronidase inhibitors and their structure-inhibitory activity relationships

• Main Authors: Tao-Shun Zhou (Author), Bin Wei (Author), Min He (Author), Ya-Sheng Li (Author), Ya-Kun Wang (Author), Si-Jia Wang (Author), Jian-Wei Chen (Author), Hua-Wei Zhang (Author), Zi-Ning Cui (Author), Hong Wang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gut microbial β-glucuronidases have the ability to deconjugate glucuronides of some drugs, thus have been considered as an important drug target to alleviate the drug metabolites-induced gastrointestinal toxicity. In this study, thiazolidin-2-cyanamide derivatives containing 5-phenyl-2-furan moiety...