Xie Zhuo Tiao Zhi formula ameliorates chronic alcohol-induced liver injury in mice

• Main Authors: Kaixin Chang (Author), Rui Guo (Author), Wenbo Hu (Author), Xuezhu Wang (Author), Feiwei Cao (Author), Jiannan Qiu (Author), Jiaomei Li (Author), Qiang Han (Author), Zhongyan Du (Author), Xiaobing Dou (Author), Songtao Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

This study aimed to evaluate the protective role and potential mechanisms of Xie Zhuo Tiao Zhi decoction (XZTZ) on alcohol-associated liver disease (ALD). XZTZ significantly alleviated alcohol-induced liver dysfunction, based on histological examinations and biochemical parameters after 4-week administration. Mechanically, alcohol-stimulated hepatic oxidative stress was ameliorated by XZTZ, accompanied by the improvement of Nrf2/Keap1 expression and alcohol-activated phosphorylation of pro-inflammatory transcription factors, including JNK, P38, P65, and IκBα, were rescued by XZTZ. In conclusion, XZTZ demonstrates potential in alleviating alcohol-induced liver injury, oxidative stress, and inflammation possibly through modulation of Nrf2/Keap1 and MAPKs/NF-κB signaling pathways, suggesting its potential as a therapeutic option for patients with alcoholic liver disease.

Item Description

1663-9812
10.3389/fphar.2024.1363131