Functional differences in the mu opioid receptor SNP 118A>G are dependent on receptor splice‐variant and agonist‐specific recruitment of β‐arrestin

• Main Authors: Casey Patrick (Author), Utibeabasi Ettah (Author), Vu Nguyen (Author), Caitlin Hart (Author), Evan Atchley (Author), Krishna Mallela (Author), Robert I. Scheinman (Author), Andrew A. Monte (Author)
• Format: Book
• Published: Wiley, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The OPRM1 gene codes for the mu opioid receptor (MOR) and polymorphisms are associated with complex patient clinical responses. The most studied single nucleotide polymorphism (SNP) in OPRM1 is adenine (A) substituted by guanine (G) at position 118 (118A>G, rs1799971) leading to a substi...