Functional differences in the mu opioid receptor SNP 118A>G are dependent on receptor splice‐variant and agonist‐specific recruitment of β‐arrestin

• Үндсэн зохиолчид: Casey Patrick (Зохиогч), Utibeabasi Ettah (Зохиогч), Vu Nguyen (Зохиогч), Caitlin Hart (Зохиогч), Evan Atchley (Зохиогч), Krishna Mallela (Зохиогч), Robert I. Scheinman (Зохиогч), Andrew A. Monte (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Wiley, 2024-08-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Abstract The OPRM1 gene codes for the mu opioid receptor (MOR) and polymorphisms are associated with complex patient clinical responses. The most studied single nucleotide polymorphism (SNP) in OPRM1 is adenine (A) substituted by guanine (G) at position 118 (118A>G, rs1799971) leading to a substi...