Activation inhibitors of nuclear factor kappa B protect neurons against the NMDA-induced damage in the rat retina

• Main Authors: Kenji Sakamoto (Author), Tatsuya Okuwaki (Author), Hiroko Ushikubo (Author), Asami Mori (Author), Tsutomu Nakahara (Author), Kunio Ishii (Author)
• Format: Book
• Published: Elsevier, 2017-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We reported that high-mobility group Box-1 (HMGB1) was involved in excitoneurotoxicity in the retina. HMGB1 is known to activate nuclear factor kappa B (NF-κB). However, the role of NF-κB in excitotoxicity is still controversial. Here, we demonstrated that NF-κB activation induced by NMDA led to...