Soluble epoxide hydrolase deficiency attenuates airway inflammation in COPD via IRE1α/JNK/AP-1 signaling pathway

• Main Authors: Yue Yu (Author), Ailin Yang (Author), Xin He (Author), Bo Wu (Author), Yanjun Wu (Author), Yunxiao Li (Author), Shan Nie (Author), Bo Xu (Author), Haoyan Wang (Author), Ganggang Yu (Author)
• Format: Book
• Published: BMC, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Soluble Epoxide Hydrolase (sEH) metabolizes anti-inflammatory epoxyeicosatrienoic acids and critically affects airway inflammation in chronic obstructive pulmonary disease (COPD). Considering the excessive endoplasmic reticulum stress is associated with the earlier onset of COPD....