Standardised imaging pipeline for phenotyping mouse laterality defects and associated heart malformations, at multiple scales and multiple stages

• Hauptverfasser: Audrey Desgrange (Verfasst von), Johanna Lokmer (Verfasst von), Carmen Marchiol (Verfasst von), Lucile Houyel (Verfasst von), Sigolène M. Meilhac (Verfasst von)
• Format: Buch
• Veröffentlicht: The Company of Biologists, 2019-07-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Laterality defects are developmental disorders resulting from aberrant left/right patterning. In the most severe cases, such as in heterotaxy, they are associated with complex malformations of the heart. Advances in understanding the underlying physiopathological mechanisms have been hindered by the...