Mitochondria and lipid raft-located FOF1-ATP synthase as major therapeutic targets in the antileishmanial and anticancer activities of ether lipid edelfosine.

• Main Authors: Janny A Villa-Pulgarín (Author), Consuelo Gajate (Author), Javier Botet (Author), Alberto Jimenez (Author), Nicole Justies (Author), Rubén E Varela-M (Author), Álvaro Cuesta-Marbán (Author), Ingrid Müller (Author), Manuel Modolell (Author), José L Revuelta (Author), Faustino Mollinedo (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Leishmaniasis is the world's second deadliest parasitic disease after malaria, and current treatment of the different forms of this disease is far from satisfactory. Alkylphospholipid analogs (APLs) are a family of anticancer drugs that show antileishmanial activity, including the first oral dr...