TLR Signalling Pathways Diverge in Their Ability to Induce PGE2

• Main Authors: Valentina Salvi (Author), Xenia Vaira (Author), Veronica Gianello (Author), William Vermi (Author), Mattia Bugatti (Author), Silvano Sozzani (Author), Daniela Bosisio (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

PGE2 is a lipid mediator abundantly produced in inflamed tissues that exerts relevant immunoregulatory functions. Dendritic cells (DCs) are key players in the onset and shaping of the inflammatory and immune responses and, as such, are well known PGE2 targets. By contrast, the precise role of human...