Comparison of intravenous sodium bicarbonate and sodium chloride combination versus intravenous sodium chloride hydration alone in reducing amphotericin B nephrotoxicity: a randomized clinical trial

• Main Authors: Iman Karimzadeh (Author), Asma Sepehr-Sobhani (Author), Mohammad Javad Khoshnoud (Author), Mohammad Mahdi Sagheb (Author), Reza Vejdani (Author), Atefeh Jalali (Author), Motahareh Mahi-Birjand (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and purpose: The most important adverse reaction of amphotericin B (AmB) is nephrotoxicity. The aim of this study was to assess the potential effectiveness of intravenous saline + sodium bicarbonate versus intravenous sodium chloride hydration in preventing or attenuating AmB nephrotoxici...