First preclinical evaluation of [225Ac]Ac-DOTA-JR11 and comparison with [177Lu]Lu-DOTA-JR11, alpha versus beta radionuclide therapy of NETs

First preclinical evaluation of [225Ac]Ac-DOTA-JR11 and comparison with [177Lu]Lu-DOTA-JR11, alpha versus beta radionuclide therapy of NETs

Abstract Background The [177Lu]Lu-DOTA-TATE mediated peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors (NETs) is sometimes leading to treatment resistance and disease recurrence. An interesting alternative could be the somatostatin antagonist, [177Lu]Lu-DOTA-JR11, that demonstrat...

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Main Authors: Maryana Handula (Author), Savanne Beekman (Author), Mark Konijnenberg (Author), Debra Stuurman (Author), Corrina de Ridder (Author), Frank Bruchertseifer (Author), Alfred Morgenstern (Author), Antonia Denkova (Author), Erik de Blois (Author), Yann Seimbille (Author)
Format: Book
Published: SpringerOpen, 2023-06-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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