Develop a 3D neurological disease model of human cortical glutamatergic neurons using micropillar-based scaffolds

• Main Authors: Cheng Chen (Author), Xin Dong (Author), Kai-Heng Fang (Author), Fang Yuan (Author), Yao Hu (Author), Min Xu (Author), Yu Huang (Author), Xixiang Zhang (Author), Danjun Fang (Author), Yan Liu (Author)
• Format: Book
• Published: Elsevier, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Establishing an effective three-dimensional (3D) in vitro culture system to better model human neurological diseases is desirable, since the human brain is a 3D structure. Here, we demonstrated the development of a polydimethylsiloxane (PDMS) pillar-based 3D scaffold that mimicked the 3D microenviro...