Host cell protein profiling of commercial therapeutic protein drugs as a benchmark for monoclonal antibody-based therapeutic protein development

• Príomhchruthaitheoirí: Rosalynn Molden (Údar), Mengqi Hu (Údar), Sook Yen E (Údar), Diana Saggese (Údar), James Reilly (Údar), John Mattila (Údar), Haibo Qiu (Údar), Gang Chen (Údar), Hanne Bak (Údar), Ning Li (Údar)
• Formáid: LEABHAR
• Foilsithe / Cruthaithe: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Ábhair: article
• Rochtain ar líne: Connect to this object online.

Therapeutic proteins including monoclonal antibodies (mAbs) are usually produced in engineered host cell lines that also produce thousands of endogenous proteins at varying levels. A critical aspect of the development of biotherapeutics manufacturing processes is the removal of these host cell prote...