Host cell protein profiling of commercial therapeutic protein drugs as a benchmark for monoclonal antibody-based therapeutic protein development

• Main Authors: Rosalynn Molden (Author), Mengqi Hu (Author), Sook Yen E (Author), Diana Saggese (Author), James Reilly (Author), John Mattila (Author), Haibo Qiu (Author), Gang Chen (Author), Hanne Bak (Author), Ning Li (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Therapeutic proteins including monoclonal antibodies (mAbs) are usually produced in engineered host cell lines that also produce thousands of endogenous proteins at varying levels. A critical aspect of the development of biotherapeutics manufacturing processes is the removal of these host cell prote...