Isotopic Radiolabeling of the Antiretroviral Drug [¹⁸F]Dolutegravir for Pharmacokinetic PET Imaging

• Main Authors: Marion Tisseraud (Author), Sébastien Goutal (Author), Thomas Bonasera (Author), Maud Goislard (Author), Delphine Desjardins (Author), Roger Le Grand (Author), Chris M. Parry (Author), Nicolas Tournier (Author), Bertrand Kuhnast (Author), Fabien Caillé (Author)
• Format: Book
• Published: MDPI AG, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Deciphering the drug/virus/host interactions at infected cell reservoirs is a key leading to HIV-1 remission for which positron emission tomography (PET) imaging using radiolabeled antiretroviral (ARV) drugs is a powerful asset. Dolutegravir (DTG) is one of the preferred therapeutic options to treat...