Selective inhibition of carbonic anhydrase IX and XII by coumarin and psoralen derivatives

• Main Authors: Rita Meleddu (Author), Serenella Deplano (Author), Elias Maccioni (Author), Francesco Ortuso (Author), Filippo Cottiglia (Author), Daniela Secci (Author), Alessia Onali (Author), Erica Sanna (Author), Andrea Angeli (Author), Rossella Angius (Author), Stefano Alcaro (Author), Claudiu T. Supuran (Author), Simona Distinto (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A small library of coumarin and their psoralen analogues EMAC10157a-b-d-g and EMAC10160a-b-d-g has been designed and synthesised to investigate the effect of structural modifications on their inhibition ability and selectivity profile towards carbonic anhydrase isoforms I, II, IX, and XII. None of t...