From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors

• Main Authors: Serena Massari (Author), Angela Corona (Author), Simona Distinto (Author), Jenny Desantis (Author), Alessia Caredda (Author), Stefano Sabatini (Author), Giuseppe Manfroni (Author), Tommaso Felicetti (Author), Violetta Cecchetti (Author), Christophe Pannecouque (Author), Elias Maccioni (Author), Enzo Tramontano (Author), Oriana Tabarrini (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The paper focussed on a step-by-step structural modification of a cycloheptathiophene-3-carboxamide derivative recently identified by us as reverse transcriptase (RT)-associated ribonuclease H (RNase H) inhibitor. In particular, its conversion to a 2-aryl-cycloheptathienoozaxinone derivative and the...