Activation of ERK-p53 and ERK-Mediated Phosphorylation of Bcl-2 Are Involved in Autophagic Cell Death Induced by the c-Met Inhibitor SU11274 in Human Lung Cancer A549 Cells

• Glavni autori: Ying Liu (Autor), Ying Yang (Autor), Yuan-Chao Ye (Autor), Qi-Feng Shi (Autor), Kuan Chai (Autor), Shin-ichi Tashiro (Autor), Satoshi Onodera (Autor), Takashi Ikejima (Autor)
• Format: Knjiga
• Izdano: Elsevier, 2012-01-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

SU11274, a small molecule inhibitor of c-Met, was reported to induce apoptosis in human non-small-cell lung cancer (NSCLC) cells. However, SU11274-mediated autophagy in NSCLC cells has rarely been reported. The aim of this study was to elucidate the molecular mechanisms mediating SU11274-induced aut...