Involvement of Nrf2-HO-1/JNK-Erk Signaling Pathways in Aconitine-Induced Developmental Toxicity, Oxidative Stress, and ROS-Mitochondrial Apoptosis in Zebrafish Embryos

• Main Authors: Qing Xia (Author), Shuo Gao (Author), Samuel Rajendran Rapael Gnanamuthu (Author), Kaiyan Zhuang (Author), Zhenzhen Song (Author), Yun Zhang (Author), Xue Wang (Author), Pengfei Tu (Author), Jianheng Li (Author), Kechun Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aconitine (AC), one of the bioactive diterpenoid alkaloids extracted from Aconitum plants, is widely used in traditional herbal medicine to treat various diseases. Emerging evidence indicates that AC has attracted great interest for its wide cardiotoxicity and neurotoxicity. However, the toxic effec...