Clofazimine modulates the expression of lipid metabolism proteins in Mycobacterium leprae-infected macrophages.

• Main Authors: Yang Degang (Author), Takeshi Akama (Author), Takeshi Hara (Author), Kazunari Tanigawa (Author), Yuko Ishido (Author), Masaichi Gidoh (Author), Masahiko Makino (Author), Norihisa Ishii (Author), Koichi Suzuki (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mycobacterium leprae (M. leprae) lives and replicates within macrophages in a foamy, lipid-laden phagosome. The lipids provide essential nutrition for the mycobacteria, and M. leprae infection modulates expression of important host proteins related to lipid metabolism. Thus, M. leprae infection incr...