Identification of Antibody and Small Molecule Antagonists of Ferroportin-Hepcidin Interaction

• Main Authors: Sandra L. Ross (Author), Kaustav Biswas (Author), James Rottman (Author), Jennifer R. Allen (Author), Jason Long (Author), Les P. Miranda (Author), Aaron Winters (Author), Tara L. Arvedson (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The iron exporter ferroportin and its ligand, the hormone hepcidin, control fluxes of stored and recycled iron for use in a variety of essential biochemical processes. Inflammatory disorders and malignancies are often associated with high hepcidin levels, leading to ferroportin down-regulation, iron...