P-I snake venom metalloproteinase is able to activate the complement system by direct cleavage of central components of the cascade.

• Main Authors: Giselle Pidde-Queiroz (Author), Fábio Carlos Magnoli (Author), Fernanda C V Portaro (Author), Solange M T Serrano (Author), Aline Soriano Lopes (Author), Adriana Franco Paes Leme (Author), Carmen W van den Berg (Author), Denise V Tambourgi (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Snake Venom Metalloproteinases (SVMPs) are amongst the key enzymes that contribute to the high toxicity of snake venom. We have recently shown that snake venoms from the Bothrops genus activate the Complement system (C) by promoting direct cleavage of C-components and generating anaphyla...