Zmiz1 is required for mature β-cell function and mass expansion upon high fat feeding

• Main Authors: Tamadher A. Alghamdi (Author), Nicole A.J. Krentz (Author), Nancy Smith (Author), Aliya F. Spigelman (Author), Varsha Rajesh (Author), Alokkumar Jha (Author), Mourad Ferdaoussi (Author), Kunimasa Suzuki (Author), Jing Yang (Author), Jocelyn E. Manning Fox (Author), Han Sun (Author), Zijie Sun (Author), Anna L. Gloyn (Author), Patrick E. MacDonald (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Identifying the transcripts which mediate genetic association signals for type 2 diabetes (T2D) is critical to understand disease mechanisms. Studies in pancreatic islets support the transcription factor ZMIZ1 as a transcript underlying a T2D GWAS signal, but how it influences T2D risk is...