High-Salt Attenuates the Efficacy of Dapagliflozin in Tubular Protection by Impairing Fatty Acid Metabolism in Diabetic Kidney Disease

• Main Authors: Meina Zou (Author), Yanrong Chen (Author), Zongji Zheng (Author), Shuyue Sheng (Author), Yijie Jia (Author), Xiangyu Wang (Author), Shijing Ren (Author), Yanling Yang (Author), Xiaomin Li (Author), Wenhui Dong (Author), Meiping Guan (Author), Qian Zhang (Author), Yaoming Xue (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

High-salt intake leads to kidney damage and even limits the effectiveness of drugs. However, it is unclear whether excessive intake of salt affects renal tubular energy metabolism and the efficacy of dapagliflozin on renal function in diabetic kidney disease (DKD). In this study, we enrolled 350 DKD...