Inhibition of Ca2+-Release-Activated Ca2+ Channel (CRAC) and K+ Channels by Curcumin in Jurkat-T Cells

• Main Authors: Dong Hoon Shin (Author), Eun Yeong Seo (Author), Bo Pang (Author), Joo Hyun Nam (Author), Hyang Sun Kim (Author), Woo Kyung Kim (Author), Sung Joon Kim (Author)
• Format: Book
• Published: Elsevier, 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The increase in cytoplasmic Ca2+ concentration (Δ[Ca2+]c) mediated by the Ca2+-release-activated Ca2+ channel (CRAC) is a critical signal for the activation of lymphocytes. Also, the voltage-gated K+ channel (Kv) and intermediate-conductance Ca2+-activated K+ channel (IKCa1/SK4) have drawn attention...