Effect of Apremilast on LPS-induced immunomodulation and inflammation via activation of Nrf2/HO-1 pathways in rat lungs

• Main Authors: Naif O. Al-Harbi (Author), Faisal Imam (Author), Mohammad Matar Al-Harbi (Author), Wajhul Qamar (Author), Khaldoon Aljerian (Author), Md. Khalid Anwer (Author), Mohammed Alharbi (Author), Sultan Almudimeegh (Author), Abdullah S. Alhamed (Author), Ali A Alshamrani (Author)
• Format: Book
• Published: Elsevier, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lipopolysaccharides (LPS), the lipid component of gram-negative bacterial cell wall, is recognized as the key factor in acute lung inflammation and is found to exhibit severe immunologic reactions. Phosphodiesterase-4 (PDE-4) inhibitor: "apremilast (AP)" is an immune suppressant and anti-i...