Metformin overcomes metabolic reprogramming-induced resistance of skin squamous cell carcinoma to photodynamic therapy

• Main Authors: Marta Mascaraque-Checa (Author), María Gallego-Rentero (Author), Jimena Nicolás-Morala (Author), Mikel Portillo-Esnaola (Author), José M. Cuezva (Author), Salvador González (Author), Yolanda Gilaberte (Author), Ángeles Juarranz (Author)
• Format: Book
• Published: Elsevier, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Cancer metabolic reprogramming promotes resistance to therapies. In this study, we addressed the role of the Warburg effect in the resistance to photodynamic therapy (PDT) in skin squamous cell carcinoma (sSCC). Furthermore, we assessed the effect of metformin treatment, an antidiabetic t...