Design and conduct considerations for studies in patients with hepatic impairment

• Главные авторы: Paulien Ravenstijn (Автор), Manoranjenni Chetty (Автор), Pooja Manchandani (Автор), Mohamed Elmeliegy (Автор), Hisham Qosa (Автор), Islam Younis (Автор)
• Формат: ‌
• Опубликовано: Wiley, 2023-01-01T00:00:00Z.
• Предметы: article
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Abstract Despite the liver being the primary site for clearance of xenobiotics utilizing a myriad of mechanisms ranging from cytochrome P450 enzyme pathways, glucuronidation, and biliary excretion, there is a dearth of information available as to how the severity of hepatic impairment (HI) can alter...