Design and conduct considerations for studies in patients with hepatic impairment

• Main Authors: Paulien Ravenstijn (Author), Manoranjenni Chetty (Author), Pooja Manchandani (Author), Mohamed Elmeliegy (Author), Hisham Qosa (Author), Islam Younis (Author)
• Format: Book
• Published: Wiley, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Despite the liver being the primary site for clearance of xenobiotics utilizing a myriad of mechanisms ranging from cytochrome P450 enzyme pathways, glucuronidation, and biliary excretion, there is a dearth of information available as to how the severity of hepatic impairment (HI) can alter...