RhoA/ROCK signalling activated by ARHGEF3 promotes muscle weakness via autophagy in dystrophic mdx mice

• المؤلفون الرئيسيون: Jae‐Sung You (مؤلف), Yongdeok Kim (مؤلف), Soohyun Lee (مؤلف), Rashid Bashir (مؤلف), Jie Chen (مؤلف)
• التنسيق: كتاب
• منشور في: Wiley, 2023-08-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Abstract Background Duchenne muscular dystrophy (DMD), caused by dystrophin deficiency, leads to progressive and fatal muscle weakness through yet‐to‐be‐fully deciphered molecular perturbations. Emerging evidence implicates RhoA/Rho‐associated protein kinase (ROCK) signalling in DMD pathology, yet i...