Antitumor Activity of a Pyrrolobenzodiazepine Antibody-Drug Conjugate Targeting LGR5 in Preclinical Models of Neuroblastoma

• Main Authors: Jianghua Tu (Author), Yukimatsu Toh (Author), Adela M. Aldana (Author), Jake J. Wen (Author), Ling Wu (Author), Joan Jacob (Author), Li Li (Author), Sheng Pan (Author), Kendra S. Carmon (Author), Qingyun J. Liu (Author)
• Format: Book
• Published: MDPI AG, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neuroblastoma (NB) is a cancer of the peripheral nervous system found in children under 15 years of age. It is the most frequently diagnosed cancer during infancy, accounting for ~12% of all cancer-related deaths in children. Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) is a me...