Changes in the pharmacokinetics of glibenclamide in rats with streptozotocin-induced diabetes mellitus
The aim of this study was to investigate the pharmacokinetics of glibenclamide (Gli) administrated orally and intravenously to normal and diabetic rats. The AUC(0-720 min) of orally administered Gli in diabetic rats (321.24 mg min/L) was greater than that (57.752 mg min/L) in normal rats. CL (0.019 ...
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| Main Authors: | , , , , |
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| Format: | Book |
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Elsevier,
2012-04-01T00:00:00Z.
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| Call Number: |
A1234.567 |
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| Copy 1 | Available |