Changes in the pharmacokinetics of glibenclamide in rats with streptozotocin-induced diabetes mellitus

• প্রধান লেখক: Yuqing Li (লেখক), Yuhui Wei (লেখক), Fan Zhang (লেখক), Dan Wang (লেখক), Xinan Wu (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2012-04-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

The aim of this study was to investigate the pharmacokinetics of glibenclamide (Gli) administrated orally and intravenously to normal and diabetic rats. The AUC(0-720 min) of orally administered Gli in diabetic rats (321.24 mg min/L) was greater than that (57.752 mg min/L) in normal rats. CL (0.019 ...