Extracellular CIRP Upregulates Proinflammatory Cytokine Expression via the NF-kappaB and ERK1/2 Signaling Pathways in Psoriatic Keratinocytes

• Main Authors: Xiu Zhang (Author), Shengbang Wang (Author), Wei Wang (Author), Liumei Song (Author), Shuo Feng (Author), Jingping Wang (Author), Tong Kang (Author), Peiwen Yang (Author), Ning Wang (Author), Pengju Yang (Author), Ruimin Bai (Author), Yongping Shao (Author), Yan Zheng (Author)
• Format: Book
• Published: Hindawi Limited, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Psoriasis is a chronic inflammatory skin disease, and elevation of proinflammatory cytokine levels is a critical driver of the pathogenesis of psoriasis. Extracellular cold-inducible RNA-binding protein (eCIRP) has been shown to play a role in various acute and chronic inflammatory diseases. C23, a...