Translation of the efficacy of antibody-drug conjugates from preclinical to clinical using a semimechanistic PK/PD model: A case study with RC88

• Main Authors: Qiaoning Li (Author), Ling Wang (Author), Jinfeng Zhang (Author), Guorui Zhao (Author), Zhihao Liu (Author), Xinting Ma (Author), Jing Jiang (Author)
• Format: Book
• Published: Wiley, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Three semimechanistic pharmacokinetic/pharmacodynamic (PK/PD) models, Simeoni, Jumbe, and Hybrid, were used for the efficacy translation of RC88 from preclinical to clinical. RC88 is a mesothelin‐targeting antibody-drug conjugate for malignant solid tumor. In the preclinical study, the rela...