Translation of the efficacy of antibody-drug conjugates from preclinical to clinical using a semimechanistic PK/PD model: A case study with RC88
Abstract Three semimechanistic pharmacokinetic/pharmacodynamic (PK/PD) models, Simeoni, Jumbe, and Hybrid, were used for the efficacy translation of RC88 from preclinical to clinical. RC88 is a mesothelin‐targeting antibody-drug conjugate for malignant solid tumor. In the preclinical study, the rela...
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| Main Authors: | , , , , , , |
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| Format: | Book |
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Wiley,
2023-07-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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