Pharmacological Characterization of RS-1259, an Orally Active Dual Inhibitor of Acetylcholinesterase and Serotonin Transporter, in Rodents: Possible Treatment of Alzheimer's Disease

• Main Authors: Yasuyuki Abe (Author), Atsushi Aoyagi (Author), Takao Hara (Author), Kazumi Abe (Author), Reina Yamazaki (Author), Yoshihiro Kumagae (Author), Shunji Naruto (Author), Kazuo Koyama (Author), Shinji Marumoto (Author), Keiko Tago (Author), Narihiro Toda (Author), Kazuko Takami (Author), Naho Yamada (Author), Mayuko Ori (Author), Hiroshi Kogen (Author), Tsugio Kaneko (Author)
• Format: Book
• Published: Elsevier, 2003-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACT: A dual inhibitor of acetylcholinesterase (AChE) and serotonin transporter (SERT), RS-1259 (4-[1S)-methylamino-3-(4-nitrophenoxy)]propylphenyl N,N-dimethylcarbamate (fumaric acid)1/2salt), was newly synthesized. RS-1259 simultaneously inhibited AChE and SERT in the brain following an oral a...