Antipsychotic profiles of TASP0443294, a novel and orally active positive allosteric modulator of metabotropic glutamate 2 receptor

• Main Authors: Hirohiko Hikichi (Author), Tetsuaki Hiyoshi (Author), Toshiyuki Marumo (Author), Yasumitsu Tomishima (Author), Ayaka Kaku (Author), Izumi Iida (Author), Hiroki Urabe (Author), Tomoko Tamita (Author), Akito Yasuhara (Author), Jun-ichi Karasawa (Author), Shigeyuki Chaki (Author)
• Format: Book
• Published: Elsevier, 2015-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glutamatergic dysfunction has been implicated in psychiatric disorders such as schizophrenia. The stimulation of metabotropic glutamate (mGlu) 2 receptor has been shown to be effective in a number of animal models of schizophrenia. In this study, we investigated the antipsychotic profiles of (2S)-5-...