Ultra-Fast Middle-Up Reversed Phase Liquid Chromatography Analysis of Complex Bispecific Antibodies Obtained in Less Than One Minute

• Autors principals: Amarande Murisier (Autor), Valentina D'Atri (Autor), Sebastian Pirner (Autor), Vincent Larraillet (Autor), Szabolcs Fekete (Autor), Matthew Lauber (Autor), Davy Guillarme (Autor)
• Format: Llibre
• Publicat: MDPI AG, 2022-10-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

This work illustrates the benefits and limitations of using ultra-short reversed phase liquid chromatography (RPLC) columns for the characterization of various complex bispecific antibodies after prolonged thermal stress at the middle-up level of analysis. First, we have demonstrated that alternativ...