IL4/IL4R signaling promotes the osteolysis in metastatic bone of CRC through regulating the proliferation of osteoclast precursors

• Main Authors: Qian Jin (Author), He Yang (Author), Zhao Jing (Author), Wu Hong-hua (Author), Song Ben-jing (Author), Wang Li-ting (Author), Ye Li-juan (Author), Xu Wei (Author), Kang Xia (Author), Wu Juan (Author), Zheng Wei (Author)
• Format: Book
• Published: BMC, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Bone metastasis of colorectal cancer (CRC) often indicates a poor prognosis. Osteolysis can be observed in metastatic sites, implying an aberrant activation of osteoclasts. However, how osteoclastogenesis is regulated in metastatic microenvironment caused by colorectal cancer is...