Active maintenance of endothelial cells prevents kidney fibrosis

• Main Authors: Seung Hee Yang (Author), Yong Chul Kim (Author), Jung Nam An (Author), Jin Hyuk Kim (Author), Juhoh Lee (Author), Hee-Yoon Lee (Author), Joo-Youn Cho (Author), Jin Ho Paik (Author), Yun Kyu Oh (Author), Chun Soo Lim (Author), Yon Su Kim (Author), Jung Pyo Lee (Author)
• Format: Book
• Published: The Korean Society of Nephrology, 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Soluble epoxide hydrolase (sEH) expressed by endothelial cells catalyzes the metabolism of epoxyeicosatrienoic acids (EETs), which are vasoactive agents. Methods: We used a unilateral ureteral obstruction mouse model of kidney fibrosis to determine whether inhibition of sEH activity redu...