Phenotypic chemical screening using a zebrafish neural crest EMT reporter identifies retinoic acid as an inhibitor of epithelial morphogenesis

• Main Authors: Laura Jimenez (Author), Jindong Wang (Author), Monique A. Morrison (Author), Clifford Whatcott (Author), Katherine K. Soh (Author), Steven Warner (Author), David Bearss (Author), Cicely A. Jette (Author), Rodney A. Stewart (Author)
• Format: Book
• Published: The Company of Biologists, 2016-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The epithelial-to-mesenchymal transition (EMT) is a highly conserved morphogenetic program essential for embryogenesis, regeneration and cancer metastasis. In cancer cells, EMT also triggers cellular reprogramming and chemoresistance, which underlie disease relapse and decreased survival. Hence, ide...