Blockade of Pannexin-1 Channels and Purinergic P2X7 Receptors Shows Protective Effects Against Cytokines-Induced Colitis of Human Colonic Mucosa

• Autores principales: Erica F. Diezmos (Autor), Irit Markus (Autor), D. S. Perera (Autor), Steven Gan (Autor), Li Zhang (Autor), Shaun L. Sandow (Autor), Paul P. Bertrand (Autor), Lu Liu (Autor)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2018-08-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Introduction: The pannexin-1 (Panx1) channels are found in many cell types, and ATP released from these channels can act on nearby cells activating purinergic P2X7 receptors (P2X7R) which lead to inflammation. Although Panx1 and P2X7R are implicated in the process of inflammation and cell death, few...