Pilot PET study of vaginally administered bioadhesive nanoparticles in cynomolgus monkeys: Kinetics and safety evaluation

• Autores principales: Molly K. Grun (Autor), Praveen Honhar (Autor), Yazhe Wang (Autor), Samantha Rossano (Autor), Minsoo Khang (Autor), Hee Won Suh (Autor), Krista Fowles (Autor), Harvey J. Kliman (Autor), Alessandra Cavaliere (Autor), Richard E. Carson (Autor), Bernadette Marquez‐Nostra (Autor), W. Mark Saltzman (Autor)
• Formato: Libro
• Publicado: Wiley, 2024-09-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Abstract Long‐lasting vaginal dosage forms could improve the therapeutic efficacy of vaginal microbicides, but achieving long‐term delivery to the vaginal canal has been a significant challenge. To advance understanding of vaginal dosage retention and biodistribution, we describe a method of noninva...