Synergistic Adverse Effects of Azithromycin and Hydroxychloroquine on Human Cardiomyocytes at a Clinically Relevant Treatment Duration

• Main Authors: Wener Li (Author), Xiaojing Luo (Author), Mareike S. Poetsch (Author), Reinhard Oertel (Author), Kapil Nichani (Author), Martin Schneider (Author), Anna Strano (Author), Marcel Hasse (Author), Robert-Patrick Steiner (Author), Lukas Cyganek (Author), Karina Hettwer (Author), Steffen Uhlig (Author), Kirsten Simon (Author), Kaomei Guan (Author), Mario Schubert (Author)
• Format: Book
• Published: MDPI AG, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Adverse effects of drug combinations and their underlying mechanisms are highly relevant for safety evaluation, but often not fully studied. Hydroxychloroquine (HCQ) and azithromycin (AZM) were used as a combination therapy in the treatment of COVID-19 patients at the beginning of the pandemic, lead...