[Ru(bpy)2(NO)SO3](PF6), a Nitric Oxide Donating Ruthenium Complex, Reduces Gout Arthritis in Mice

• Main Authors: Ana C. Rossaneis (Author), Daniela T. Longhi-Balbinot (Author), Mariana M. Bertozzi (Author), Victor Fattori (Author), Carina Z. Segato-Vendrameto (Author), Stephanie Badaro-Garcia (Author), Tiago H. Zaninelli (Author), Larissa Staurengo-Ferrari (Author), Sergio M. Borghi (Author), Thacyana T. Carvalho (Author), Allan J. C. Bussmann (Author), Florêncio S. Gouveia (Author), Luiz G. F. Lopes (Author), Rubia Casagrande (Author), Waldiceu A. Verri (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Monosodium urate crystals (MSU) deposition induces articular inflammation known as gout. This disease is characterized by intense articular inflammation and pain by mechanisms involving the activation of the transcription factor NFκB and inflammasome resulting in the production of cytokines and oxid...