Breviscapine remodels myocardial glucose and lipid metabolism by regulating serotonin to alleviate doxorubicin-induced cardiotoxicity

• Main Authors: Meng-Jiao Li (Author), Wen-She Sun (Author), Yang Yuan (Author), Yu-Kun Zhang (Author), Qi Lu (Author), Yuan-Zhen Gao (Author), Ting Ye (Author), Dong-Ming Xing (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aims: The broad-spectrum anticancer drug doxorubicin (Dox) is associated with a high incidence of cardiotoxicity, which severely affects the clinical application of the drug and patients' quality of life. Here, we assess how Dox modulates myocardial energy and contractile function and this coul...