Structure-based design, synthesis, and biological evaluation of novel pyrimidinone derivatives as PDE9 inhibitors

• Үндсэн зохиолчид: Xu-Nian Wu (Зохиогч), Ya-Dan Huang (Зохиогч), Jin-Xuan Li (Зохиогч), Yan-Fa Yu (Зохиогч), Zhou Qian (Зохиогч), Chen Zhang (Зохиогч), Yinuo Wu (Зохиогч), Hai-Bin Luo (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Elsevier, 2018-07-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

The pathological processes of Alzheimer's disease and type 2 diabetes mellitus have been demonstrated to be linked together. Both PDE9 inhibitors and PPARγ agonists such as rosiglitazone exhibited remarkable preclinical and clinical treatment effects for these two diseases. In this study, a ser...