Structure-based design, synthesis, and biological evaluation of novel pyrimidinone derivatives as PDE9 inhibitors

• Main Authors: Xu-Nian Wu (Author), Ya-Dan Huang (Author), Jin-Xuan Li (Author), Yan-Fa Yu (Author), Zhou Qian (Author), Chen Zhang (Author), Yinuo Wu (Author), Hai-Bin Luo (Author)
• Format: Book
• Published: Elsevier, 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The pathological processes of Alzheimer's disease and type 2 diabetes mellitus have been demonstrated to be linked together. Both PDE9 inhibitors and PPARγ agonists such as rosiglitazone exhibited remarkable preclinical and clinical treatment effects for these two diseases. In this study, a ser...