Establishment and characterization of arsenic trioxide resistant KB/ATO cells

• Main Authors: Yun-Kai Zhang (Author), Chunling Dai (Author), Chun-gang Yuan (Author), Hsiang-Chun Wu (Author), Zhijie Xiao (Author), Zi-Ning Lei (Author), Dong-Hua Yang (Author), X. Chris Le (Author), Liwu Fu (Author), Zhe-Sheng Chen (Author)
• Format: Book
• Published: Elsevier, 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Arsenic trioxide (ATO) is used as a chemotherapeutic agent for the treatment of acute promyelocytic leukemia. However, increasing drug resistance is reducing its efficacy. Therefore, a better understanding of ATO resistance mechanism is required. In this study, we established an ATO-resistant human...