Design of antibody variable fragments with reduced reactivity to preexisting anti-drug antibodies

• Main Authors: Maria U. Johansson (Author), Christopher Weinert (Author), Dietrich Alexander Reichardt (Author), Dana Mahler (Author), Dania Diem (Author), Christian Hess (Author), Diana Feusi (Author), Simon Carnal (Author), Julia Tietz (Author), Noreen Giezendanner (Author), Fabio Mario Spiga (Author), David Urech (Author), Stefan Warmuth (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTUpon reformatting of an antibody to single-chain variable fragment format, a region in the former variable/constant domain interface of the heavy chain becomes accessible for preexisting (PE) anti-drug antibody (ADA) binding. The region exposed because of this reformatting contains a previou...