Inhibiting Lung Lining Fluid Glutathione Metabolism with GGsTop as a Novel Treatment for Asthma

• Main Authors: Marina eTuzova (Author), Jyh-Chang eJean (Author), Rebecca P. eHughey (Author), Lou Ann Scism Brown (Author), William eCruikshank (Author), Jun eHiratake (Author), Martin eJoyce-Brady (Author)
• Format: Book
• Published: Frontiers Media S.A., 2014-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Asthma is characterized by airway inflammation. Inflammation is associated with oxidant stress. Airway epithelial cells are shielded from this stress by a thin layer of lung lining fluid (LLF) which contains an abundance of the antioxidant glutathione. LLF glutathione metabolism is regulated by γ-gl...